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Characterization of lipid nanoparticles for mRNA delivery by capillary electrophoresis and Taylor dispersion analysis - Job Opportunity at Université de Montpellier

Montpellier, France
Contract
Entry-level
Posted: March 8, 2025
On-site
EUR 35,000-40,000 per year (standard French doctoral contract rate)

Benefits

Access to state-of-the-art research facilities in new Pôle Chimie Balard building
Prestigious research environment at CNRS Campus
Collaboration opportunities with leading researchers
Professional development through interdisciplinary research

Key Responsibilities

Develop CE and TDA analytical methodologies for LNP characterization
Study interactions between LNPs and serum proteins
Characterize size of LNP protein corona using TDA
Determine charge and isoelectric point of LNP protein corona by CE
Conduct frontal CE analysis for LNP-protein interactions
Optimize methods to limit LNP adsorption to capillary surfaces

Requirements

Education

Master's degree in analytical chemistry or physical chemistry

Required Skills

Advanced English proficiency Analytical chemistry expertise Physical chemistry knowledge Interdisciplinary research capabilities Independence and curiosity French language (preferred but not required)
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Industry Trends

The mRNA vaccine sector is experiencing unprecedented growth following COVID-19, creating high demand for analytical expertise Increasing focus on lipid nanoparticle characterization methods as mRNA delivery becomes central to modern vaccine development Growing importance of miniaturized analytical techniques in pharmaceutical development

Role Significance

Small research team environment with three senior supervisors and likely 5-10 fellow researchers
Doctoral researcher position with significant autonomy in method development and research direction

Key Projects

Development of novel analytical methods for LNP characterization Optimization of protein corona analysis techniques Advancement of capillary electrophoresis applications in vaccine development

Success Factors

Strong foundation in analytical chemistry principles and instrumentation Ability to work independently while maintaining collaborative relationships Creative problem-solving skills for method development challenges Clear scientific communication abilities for publishing and presenting findings

Market Demand

High demand for specialists in LNP characterization due to expanding mRNA therapeutics field

Important Skills

Critical Skills

Analytical method development expertise for complex biological systems Understanding of lipid nanoparticle chemistry and characterization Data analysis and interpretation skills for multiple analytical techniques

Beneficial Skills

Programming skills for data analysis automation Experience with pharmaceutical development processes Knowledge of regulatory requirements for analytical method validation

Unique Aspects

Focus on cutting-edge mRNA delivery technology during industry expansion phase
Access to advanced analytical facilities and expertise
Combination of fundamental research with pharmaceutical applications

Career Growth

3-year doctoral program with potential post-doctoral opportunities

Potential Next Roles

Senior Scientist in pharmaceutical analytics Research Team Leader in bioanalytical chemistry Principal Investigator in academic research Method Development Specialist in biotechnology industry

Company Overview

Université de Montpellier

Leading French public research university with strong emphasis on chemistry and life sciences

Prominent position in European academic research with strong industry connections
Major research hub in southern France with international collaborations
Academic research environment emphasizing innovation and scientific excellence
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