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PhD Position - Exploring and Exploiting the Biosynthesis of Antimicrobial Lipopeptides - Job Opportunity at Université Paris-Saclay GS Santé et médicaments

Gif-sur-Yvette, France
Full-time
Entry-level
Posted: February 26, 2025
On-site
EUR 25,000-30,000 per year (standard French PhD stipend range)

Benefits

Funded PhD position through ED Program
Access to advanced research facilities
Academic research environment
Professional development opportunities

Key Responsibilities

Conduct research on lipopeptide biosynthesis mechanisms
Analyze protein structures and protein-protein interfaces
Design and execute enzyme engineering experiments
Develop biosynthetic pathways for novel antimicrobial compounds
Document and publish research findings

Requirements

Education

Master 2 degree (or equivalent) in Chemistry, Biochemistry, Microbiology, Molecular Biology, or Chemistry of Natural Substances

Experience

Prior experience with protein expression and purification

Required Skills

Protein expression and purification Structural analysis methods (X-ray crystallography, NMR spectroscopy, cryo-EM) Enzyme function analysis (HPLC and LC-MS) Technical English proficiency Organization and project management Research methodology
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Sauge AI Market Intelligence

Industry Trends

The antimicrobial resistance crisis is driving increased funding and research focus in novel antibiotic development Integration of synthetic biology with traditional pharmaceutical research is creating new opportunities in drug discovery Growing emphasis on sustainable and scalable production methods for pharmaceutical compounds

Role Significance

Typically part of a research group of 5-10 members, with collaboration across multiple institutional departments
Entry-level research position with significant potential for scientific impact in antimicrobial drug development

Key Projects

Development of novel antimicrobial compounds Structural characterization of biosynthetic enzymes Optimization of biosynthetic pathways Drug resistance mechanism studies

Success Factors

Strong foundation in biochemistry and structural biology Ability to integrate multiple analytical techniques Publication record in peer-reviewed journals Successful completion of doctoral thesis

Market Demand

High demand for specialists in antimicrobial research due to global health challenges and increasing antibiotic resistance

Important Skills

Critical Skills

Protein biochemistry expertise Structural biology techniques Analytical chemistry methods Data analysis and interpretation

Beneficial Skills

Programming skills for data analysis Experience with automation systems Project management capabilities Scientific writing skills

Unique Aspects

Focus on urgent global health challenge of antimicrobial resistance
Integration of multiple cutting-edge analytical techniques
Potential for direct impact on drug development
Access to world-class research infrastructure

Career Growth

3-4 years for PhD completion, with potential for immediate industry or postdoctoral positions afterward

Potential Next Roles

Postdoctoral Researcher Research Scientist in Pharmaceutical Industry Biotechnology Research Lead Academic Faculty Position

Company Overview

Université Paris-Saclay GS Santé et médicaments

Leading French research institution with strong focus on health sciences and drug development

Top-tier European academic institution with significant research funding and international collaborations
Central player in Paris-Saclay research ecosystem
Academic environment with emphasis on innovation and international collaboration
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