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PhD Position - New therapeutic approach for Alzheimer's disease by targeting brain energy metabolism - Job Opportunity at IRMETIST INSERM U1313

Poitiers, France
Temporary
Entry-level
Posted: February 27, 2025
On-site
EUR 20,000-25,000 per year (standard French PhD stipend range)

Benefits

Funded PhD position through Ministry/Region Nouvelle Aquitaine
Access to advanced research facilities and equipment
Academic research environment with publication opportunities
Integration into established research team

Key Responsibilities

Conduct research on lactate-based neuroprotective mechanisms in Alzheimer's disease
Perform in vivo studies using rodent models and MRI analysis
Execute in vitro studies on astrocyte cultures and neuron/astrocyte co-cultures
Analyze and document research findings
Contribute to academic publications and presentations

Requirements

Education

Master's degree in Neuroscience or related biological field

Experience

Research experience in cellular and molecular biology

Required Skills

Cellular and molecular biology knowledge Biochemistry expertise Animal physiology understanding Cell culture experience Immunohistochemistry proficiency Fluorescence microscopy skills Animal behavior analysis Laboratory organizational skills

Certifications

Animal experimentation certification (preferred)
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Sauge AI Market Intelligence

Industry Trends

The field of neurometabolic research in Alzheimer's disease is experiencing significant growth, with increasing focus on alternative energy pathways beyond traditional glucose metabolism FGF21-based therapeutics are emerging as a promising area in neurodegenerative disease treatment, with multiple pharmaceutical companies investing in this approach Integration of metabolic and neurological research is creating new opportunities for therapeutic interventions in brain disorders

Role Significance

Likely part of a focused research team of 5-10 researchers, including Principal Investigator, post-docs, and other PhD students
Entry-level research position with significant potential for scientific contribution and academic development

Key Projects

Development of lactate-based therapeutic approaches for Alzheimer's disease Investigation of FGF21's role in neuroprotection Analysis of brain energy metabolism in neurodegenerative conditions

Success Factors

Strong foundation in molecular biology and biochemistry Ability to manage complex experimental protocols Effective documentation and analysis skills Independent research capabilities with collaborative mindset Publication-oriented research approach

Market Demand

High demand for researchers in neurodegenerative disease therapeutics, particularly those with expertise in metabolic pathways and novel therapeutic approaches

Important Skills

Critical Skills

Advanced laboratory techniques in cell culture and microscopy Understanding of brain metabolism and neurodegeneration Experimental design and analysis capabilities Scientific writing and documentation skills

Beneficial Skills

Programming skills for data analysis Advanced imaging techniques Grant writing experience Scientific presentation skills

Unique Aspects

Novel approach to Alzheimer's treatment through metabolic pathway manipulation
Integration of multiple research techniques from molecular to behavioral studies
Potential for high-impact publications in emerging therapeutic field

Career Growth

3-4 years for PhD completion, with potential for immediate transition to postdoctoral or industry positions

Potential Next Roles

Postdoctoral Researcher Research Scientist in Pharmaceutical Industry Academic Faculty Position Drug Development Researcher

Company Overview

IRMETIST INSERM U1313

INSERM is France's premier public research institution in health and medical research, providing strong institutional support and research infrastructure

Leading position in French biomedical research with strong international collaborations
Major research center in Nouvelle Aquitaine region, offering significant research opportunities and resources
Academic research environment fostering innovation and collaboration, with strong emphasis on publication and scientific impact
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