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Senior Research Associate - Bioinformatics - Job Opportunity at OrthoBio Therapeutics

Cambridge, United Kingdom
Contract
Senior
Posted: February 25, 2025
On-site
GBP 55,000-70,000 per year

Benefits

Comprehensive healthcare package with private medical insurance indicating investment in employee wellbeing
Enhanced parental benefits (maternity/paternity) exceeding statutory requirements
Future-focused benefits including cycle-to-work scheme and casual dress code
Strong financial security package including life insurance and company pension
Work-life balance support through flexible sick pay policy
International talent support through UK visa sponsorship
On-site amenities including staff canteen

Key Responsibilities

Lead development and optimization of CRISPR design pipelines incorporating advanced machine learning algorithms
Spearhead computational analysis of gene editing outcomes to drive therapeutic development
Direct RNA sequencing analysis workflows for novel target identification
Guide implementation of cutting-edge biocomputational methods for CRISPR applications
Conduct advanced statistical analysis of experimental data to inform therapeutic development

Requirements

Education

PhD (required)

Experience

2 years post-university experience (required)

Required Skills

Highly proficient in bioinformatics programming using Python and R Expertise in pipeline scripting and automation using HPC clusters Expertise with Linear Regression Models and Machine Learning Expertise in analysing bulk and single-cell RNA sequencing data Excellent skills in biostatistical analysis and modelling Excellent analytical and problem-solving skills Strong communication and interpersonal skills Independent thinking and effective multi-tasking abilities
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Sauge AI Market Intelligence

Industry Trends

The gene editing therapeutics sector is experiencing rapid growth, with CRISPR-based treatments moving into clinical trials across multiple disease areas Integration of machine learning with CRISPR design represents a cutting-edge approach that's becoming increasingly crucial for therapeutic development Musculoskeletal disease treatment through gene editing is an emerging field with significant market potential and relatively low competition

Salary Evaluation

The offered salary range of £55,000-70,000 is competitive for a senior bioinformatics role in Cambridge's biotech sector, aligning with market rates for similar positions in leading gene therapy companies

Role Significance

Likely part of a small but growing R&D team of 5-10 scientists, typical for an early-stage biotech company
Senior individual contributor role with significant influence on therapeutic development pipeline and potential for technical leadership

Key Projects

Development of novel CRISPR delivery systems for musculoskeletal applications Optimization of gene editing efficiency through machine learning approaches Target identification and validation through comprehensive genomic analysis

Success Factors

Deep expertise in both computational methods and biological applications Ability to bridge wet-lab and computational research effectively Strong project management skills in a fast-paced startup environment Capacity to translate complex analytical results into actionable therapeutic strategies

Market Demand

Very high demand with limited talent pool, particularly for candidates combining CRISPR expertise with advanced computational skills

Important Skills

Critical Skills

Advanced machine learning expertise for CRISPR design optimization Deep understanding of gene editing technology and applications Strong statistical analysis capabilities for experimental data interpretation

Beneficial Skills

Experience with lipid nanoparticle delivery systems Knowledge of musculoskeletal disease biology Familiarity with clinical development processes

Unique Aspects

Access to world-class scientific advisory board including Moderna co-founder
Focus on novel combination of CRISPR and nonviral delivery methods
Strategic location in Europe's largest biomedical campus

Career Growth

2-3 years potential advancement timeline given company's growth stage and field dynamics

Potential Next Roles

Technical Lead - Bioinformatics Head of Computational Biology Director of R&D

Company Overview

OrthoBio Therapeutics

Early-stage biotech company with strong academic ties and world-class scientific advisory board, including prominent figures from leading institutions

Well-positioned in the emerging gene therapy space with unique focus on musculoskeletal applications
Strategically located in Cambridge's biotech hub with strong potential for expansion
Fast-paced startup environment with strong academic influence and focus on innovation
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